The explosive demand for semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) led to significant drug shortages over the past several years, opening a market for compounded versions of these medications. Compounded semaglutide is available through various online platforms, telehealth services, and compounding pharmacies — often at a fraction of the cost of branded products. Understanding the risks, regulatory status, and what to look for is critical before pursuing this option.
What Is Compounded Semaglutide?
Compounded medications are customized preparations made by licensed compounding pharmacies, typically when an FDA-approved version is unavailable, unsuitable for a patient, or discontinued. During periods of documented drug shortage, compounding pharmacies were legally permitted to compound copies of semaglutide and tirzepatide. As of late 2024 and into 2025, the FDA has resolved the shortage status for some formulations, significantly changing the regulatory landscape for compounded versions. The FDA has issued guidance indicating that compounding of semaglutide is generally not appropriate once the shortage has been officially resolved.
Risks to Understand
- Compounded products are not FDA-approved — they have not undergone the same efficacy and safety review process
- Some compounded semaglutide products have used semaglutide sodium or acetate salt instead of the base molecule used in Ozempic/Wegovy — these are chemically distinct and not equivalent
- Quality control varies significantly between compounding pharmacies — concentration accuracy and sterility cannot be assumed
- Without physician oversight, dosing errors, drug interactions, and contraindications may be missed
What Physician Supervision Provides
Regardless of which version of semaglutide you use, physician supervision ensures appropriate candidacy screening, correct dosing, side effect management, and integration with your overall health care. Dr. Arpana Pillay at Vish Medical can discuss GLP-1 medication options — branded and otherwise — in the context of your individual health situation. Book a consultation to get evidence-based guidance on your weight loss options.